摘要
早期胃癌(EGC)病变局限,若能及早诊断治疗,预后良好。近年来,大规模临床筛查的普及,仿真内镜、多种新型胃镜等的应用,使早期胃癌的检出率明显提高。随着分子生物学技术的发展,发现早期胃癌的发生与癌基因c-myc、p53、p16等的突变、端粒酶活性变化、微卫星DNA的不稳定性等密切相关。
Early gastric cancer (EGC) lesions are limited, the prognosis is good if timely diagnosed and treated. In recent years, with the popularity of large-scale clinical screening, the application of virtual endoscopy and several new endoscopes, the detection rate of EGC has improved significantly. With the develop- ment of molecular biology techniques, researches find that oncogene c- myc,p53, p16 mutation, telomerase activity,microsatellite DNA instability and so on are closely related with the genesis of EGC.
出处
《国际肿瘤学杂志》
CAS
2007年第6期463-466,共4页
Journal of International Oncology
关键词
胃肿瘤
诊断
胃镜检查
分子生物学
Stomach neoplasms
Diagnosis
Gastroscopy
Molecular biology