青年与中老年胃癌临床病理特征比较

Comparative analysis of clinicopathologic features of gastric cancinoma in the old and young patients

目的探讨青年胃癌患者的特殊临床病理特征。方法回顾性分析住院胃癌患者364例，其中青年（年龄≤40岁）36例，中老年（年龄〉40岁）328例，比较二者临床病理特征。数据通过X^2检验进行统计分析，P〈0．05为有统计学意义。结果364例胃癌患者中，36例（9．9％）符合青年胃癌的诊断，其中女性多（P=0．022）。有如下特征：消化道出血的发生率低（P=0．017）；局限在黏膜及黏膜下的T1期肿瘤比例增高（P=0．045）；低-未分化腺癌比例明显增高（P=0．001）；印戒细胞癌比例明显增高（P=0．000）。结论青年胃癌具有女性多见、消化道出血的发生率低、浸润性强、恶性程度高、预后不良等特征，应加强对青年胃癌的认识及警惕。

Objective To find out the specific clinicopathologic characteristics of young gastric carcinoma patients. Methods A total of 364 patients with gastric carcinoma, including 36 cases of young patients （ age ≤40） and 328 cases of elder patients （age 〉40） , were involved in this retrospectively study. The X^2-test was employed to evaluate the statistical significance of difference and P 〈 0.05 was considered to have statistical significance. Results In all 364 patients with gastric carcinoma, 36 （ 9.9% ） were divided into the young age group. The female/male ratio was significantly increased in young patients （ P =0.022）, The incidence of digestive tract hemorrhage was much lower in the young patients（ P = 0. 017 ）, while the ratio of type T1 tumor was significantly increased in the young group （ P = 0. 045 ）, Significantly increased in young patients were poorly differentiated （ P = 0.001 ） and with signet ring cell carcinoma （ P = 0.000）. Conclusion Gastric carcinoma in young patients has higher percentage of female patients, lower incidence of digestive tract hemorrhage, deeper invasion, higher malignity and worse prognosis. Physicians must enhance the knowledge and awareness of gastric carcinoma in young patients.