食管癌中Survivin蛋白的表达及其意义

Expression and significance of Survivin in esophageal carcinoma

目的:探讨Survivin蛋白在食管癌组织中的表达和临床意义。方法:采用免疫组化方法检测61例食管鳞癌手术切除标本及26例癌旁组织的Survivin蛋白表达情况。结果:食管鳞癌组织Survivin阳性表达率为60.7%(37/61);Survivin表达与肿瘤病理分级、浸润深度、临床分期、淋巴结转移和患者生存期有明显相关性(P<0.01)。结论:Survivin的表达可以作为判断食管癌恶性潜能的重要生物学指标,对于临床选择高危复发病例给予积极治疗,提高预后水平具有重要意义。

Objective：To investigate the expression and clinical significance of Survivin in esophageal carcinoma and explore the relationship between them. Methods： Survivin was detected by SABC immunohistochemistry in 61 cases of esophageal carcinoma tissue and 26 cases of tumor-adjacent normal tissue. Results： The positive Survivin expression rate was 60.7% in tumor tissue compared with 19.3% in tumor-adjacent normal tissue （P 〈 0.01）. The Survivin expression showed higher positive correlation with the tumor grading, infiltration, lymph node metastasis and the prognosis of patients as well. Conclusion：The abnormal expression of Survivin was associated with the occurrence and progression of esophageal carcinoma. Survivin may be an important marker for tumor diagnosis and its expression level be benefit to monitor prognosis.