脑卒中后抑郁血浆单胺递质的变化及氟西汀对其影响

The changes of monamine transmitter content in plasm of post-stroke depression patients and the effect of fluoxetine hydrochloride to post-stroke depression treatment

目的:探讨脑卒中后抑郁(PSD)血浆单胺递质的变化及盐酸氟西汀对其治疗影响。方法:将160例患者按照1995年脑卒中诊断标准、汉密尔顿抑郁量表(HAMD)评定、中国精神疾病分类方案与诊断标准第三版(CCMD-3)分为4组:盐酸氟西汀胶囊抗抑郁治疗组40例(PSD抗抑郁治疗组)、非抗抑郁治疗组40例(PSD非抗抑郁治疗组)、脑卒中组40例(非PSD),正常组40例(正常对照组)。采用荧光分光光度仪测定治疗前和治疗后的NE、5-HT的含量。结果:PSD组经盐酸氟西汀胶囊治疗后HAMD评分下降,抑郁症状减轻。PSD患者血浆NE、5-HT含量下降,在抗抑郁治疗后,NE、5-HT含量上升。结论:PSD与单胺递质含量降低有关,氟西汀能改善卒中后抑郁及认知功能。

Objective：To investigate the changes of monamine transmitter content in plasm of post-stroke depression （PSD） patients and the effect of fluoxetine hydrochloride to PSD treatment.nethods：160 patients were divided into four groups：40 patients in the treatment group of fluoxetine hydrochloride to resist depression（the treatment group of anti-depression PSD）,40 patients in the treatment group of negative anti-depression （the treatment group of negative anti-depression PSD）,40 patients in the stroke group （negative PSD） and 40 health people in the normal control group （the normal control group） by the standard of stroke scale is 1995,and the evaluation of hamilton depression scale（HAMD）,Chinese classification and diagnostic criteria of mental disorders-3（CCMD-3）.The contents of NE and 5-HT were measured by fluorescence-spectrophotometer instrument pretherapy and pest-treatment.Results：The scores of HAMD were decreased after treatment of fluoxetine hydrochloride and the symptom of depression was improved in PSD group.The contents of NE and 5- HT were decreased in plasm of PSD patients,and the contents of NE and 5-HT were inreased after anti-depression treatment.Conclusion： PSD was related to the decrease of the content of monoamine transmitter.Fluoxetine hydrochloride could improve the symptom of depres- sion and cognitive function.