尿IgG与小儿过敏性紫癜复发之间关系的探讨

To Study the Relationship between the IgG in Urine and Recurrence of Anaphylactoid Purpura in Children

目的 探讨小儿过敏性紫癜首次住院时尿IgG与1年内复发的关系。方法 用免疫比浊法测定28例出院后1年内出现复发的和38例出院后1年内无复发的过敏性紫癜患儿首次住院时急性期和恢复期的尿IgG,并加以比较分析。结果 出院后1年内出现复发的患儿其首次住院急性期尿IgG的水平为（1.766±0.752）g/L,与出院后1年内无复发者相若,而恢复期尿IgG的水平为（0.245±0.061）g/L,明显高于无复发者的（0.113±0.055）g/L,其差异有非常显著性意义（P〈0.01）。结论 大部分过敏性紫癜患儿在急性期均有一定程度的肾损害,1年内复发的过敏性紫癜患儿其首次发病临床症状虽然基本消失,而肾损害仍存在,小血管炎没有完全消失,其病理改变仍持续存在,致紫癜易于复发。尿IgG在判断小儿过敏性紫癜的活动方面和复发的预后方面均有一定的意义。

Objective To study the relationship between the IgG in urine and relapse in a year of children with anaphylactoid purpura in first visit. Methods Urinary IgG in acute stage and recovery phase were assayed by immunoturbidimetry respectively of 28 patients with recurrence and 38 patients without relapse in a year. Results Level of children urinary IgG with recurrence in acute stage is （1.766±0.752）g/L, there was not any difference in the control group, obviously, Level of children urinary IgG with recurrence in recovery phase is （0.245 ±0. 061）g/L, the others is （0.113 ±0.055）g/ L, the differences were extremely significant （P〈0. 01）. Conclusions The renal pathological was observed in many children with anaphylactoid purpura in acute stage, there were not any symptoms among the children with recurrence in a year, but there were polyangitis consistently, the cause of relapse is polyangitis. So, the IgG in urine could be used to assess the recurrence and prognosis of anaphylactoid purpura in hospitalized children.