骨桥蛋白和CD44v6在非小细胞肺癌中的表达及意义

Overexpression of osteopontin and CD44v6 in the non-small cell lung cancer

目的:探讨骨桥蛋白(OPN)和CD44v6在非小细胞肺癌中的表达与肺癌临床病理的关系。方法:应用免疫组织化学方法,分别检测OPN和CD44v6在56例非小细胞肺癌(30例鳞癌和26例腺癌)组织中的表达。结果:(1)56例非小细胞肺癌组织中OPN和CD44v6阳性表达率分别为71.4%、67.8%。肺鳞癌组和肺腺癌组中OPN和CD44v6的表达无差异性(P>0.05)。(2)肺癌中OPN和CD44v6的表达与肿瘤的淋巴结转移相关(P<0.05),而与患者的年龄、性别及肿瘤组织学分级无关(P>0.05)。结论:OPN和CD44v6可能在肺癌的发生、进展中起重要作用,联合检测OPN、CD44v6可作为判断肺癌患者预后的重要指标。

Objective：To explore the expression and role of osteopontin （OPN） and CD44v6 in the non-small cell lung cancer and analyze the relationship between its expression and clinicopathologic features. Methods：The expression of OPN and CD44v6 was studied by immunohistochemistry in 56 cases of non-small cell lung carcinoma tissues. Results：In 56 cases of non-small cell lung carcinoma tis- sues, the expression rates of OPN and CD44v6 were 71.4%,67.8%,respectively. There was a strong correlation between the expression of OPN and CD44v6 in non-small ceil lung cancer, it was obviously related with tumor degree of lymphatic vessel invasion or long distant lymph node metastases（P〈0.05）. Conclusion：OPN and CD44v6 may play an important role in the progression of non-small ceil lung carcinomas and they may involve in the invasion and metastasis of non-small ceil lung carcinomas.