左氧氟沙星联合微卡治疗复治老年肺结核疗效的观察

Therapeutic effect of M.poleis vaccine combined with levofloxacin in senile pulmonary tuberculosis

目的:观察和评价含有左氧氟沙星的化疗方案联合应用微卡(母牛分枝杆菌)治疗复治老年肺结核的疗效。方法:将97例老年肺结核患者随机分为:治疗组(V+M组)50例,对照组(H组)47例;化疗方案:治疗组4VHZM/5VHL3,对照组4HZO/5HZO。观察两组痰菌阴转率、病灶吸收率、空洞闭合率以及免疫功能改善情况。结果:治疗组痰菌阴转率、病灶吸收率、空洞直径缩小率分别为84%、85%、66%,明显高于对照组的42%、35%、26%(P<0.01)。治疗组CD3、CD4较治疗前明显升高,CD8明显降低,CD4/CD8比值升高,两组不良反应率差异无显著性(P>0.05)。结论:左氧氟沙星与微卡联用可提高复治老年肺结核的疗效,使用安全。

Objective：To observe the therapeutic effect of senile pulmonary tuberculosis treated by the protocol of levofloxaein combined myeobaeterium poleis vaccine （MPV）.Methods：97 senile patients with pulmonary tuberculosis were divided into the treatment group （group M with 50 eases） and control group （this group with 47 eases）,their protocols were 4VHZM/SVHL5 and 4HZO/SHZO respectively.The sputum negative conversion rate,focal absorption,pulmonary cavity closure and improvement of the immunity were observed respectively.Results：The sputum negative conversion rate,the focal absorption rate and cavity closure rate in the group M were 84%,85% and 66% respectively,significantly higher than 42% ,35% and 26% in the control group （P〈0.01）.The lymphocyte subgroups of CD3 and CD4 elevated significantly,while CDs decreased significantly and the ratio of CD4 to CDs increased after treatment.The incidence rates of adverse reaction in the two groups were comparable （P〉0.05）.Conclusion：MPV can improve the therapeutic effect and safety in senile pulmonary tuberculosis.