巨幼细胞性贫血50例临床分析

Clinical analysis of 50 patients with megaloblastic anemia

目的:探讨巨幼细胞性贫血患者的临床特点。方法:对1999年1月～2006年6月我院收治的巨幼细胞性贫血进行回顾性分析。结果:所有病例均血红蛋白减少,TBIL升高者35例(70%),维生素B12、叶酸治疗总有效率达95.4%。结论:巨幼细胞性贫血的临床表现无特异性,血清叶酸、维生素B12检测是诊断的重要手段,临床治疗为补充叶酸、维生素B12,疗效佳。

Objective：To analyse the presenting features and laboratory features of the patients with megaloblastic anaemia（MA）. Methods：The clinical data in 26 patients with MA in our hospital between January 1999 and June 2006 were restyospetively reviewed. Results：MA was common in clinic ,vitamin B12 deficiency was found in all cases.The most common presenting symptoms were fatigue ,otherwise there were gastroenteric and neural symptoms. Hemoglobin was lower in all cases. The effective rate of vitamin B,, and folate was 95.4%. Conclusion ：The clinical symptom of MA is nonspecific.The test of vitamin B12 and folate is a major disagnostic approach. The treatment is additional vitamin B12 and folate, the effect of treatment is good.