嗜酸性粒细胞浸润对鼻息肉术后鼻腔黏膜转归及疗效的影响

Eosinophil infiltration on the regeneration of nasal mucosa following nasal endoscopic sinus surgery

目的:探讨嗜酸性粒细胞(eosinophils,EOS)浸润对鼻息肉术后鼻腔黏膜转归及疗效影响的因素。方法:对于50例鼻息肉患者术中及部分术后复发的鼻息肉组织和上颌窦口周边水肿组织采用Chromo-trope 2R特染,检测以上标本中嗜酸性粒细胞在功能性鼻窦内窥镜术后术腔黏膜恢复过程中的表达水平,并进行相关分析。结果:鼻息肉组织中EOS水平明显高于中鼻甲黏膜组织,且随时间呈现不同的变化规律(P<0.01);EOS浸润程度越深,鼻腔黏膜恢复越慢,鼻息肉复发越快。结论:EOS浸润在鼻息肉的形成和发展中起重要作用,提示其可能参与延迟鼻窦、鼻腔黏膜上皮化的进程,可作为疗效判断的指标之一。

Objective： To explore the eosinophil infiltration on the transitionary process of nasal mucosa following nasal endoscopic surgery. Methods： Eosinophil was quantitatively determined in polyps and recurrent polyps and edema tissues around the maxillary sinus by Chromotrope 2R staining. Results： Eosinophil was higher in polyps than in the middle turbinate （P 〈 0.01 ）. The recurrence rate was highly correlated with the eosinophil infiltration in the tissues. Conclusion： Eosinophil infitration is directly related to the recurrence of polyps, which can be regarded as a prognostic indicator for polyps.