低温射频消融术治疗阻塞性睡眠呼吸暂停低通气综合征

Temperature-controlled radio-frequency ablation in treatment of obstructive sleep apnea hypopnea syndrome

目的:探讨低温射频消融术(temperature-controlled radiofrequency ablation,TCRF)治疗阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的疗效和手术前后生活质量的变化。方法:对50例OSAHS患者行TCRF治疗,比较治疗前后呼吸暂停低通气指数(apnea hypopnea index,AHI)、最低血氧饱和度(lowest arterial oxygeon saturation,LSaO2)、Epworth嗜睡评分(Epworth Sleepiness Scale,ESS)和Calgary生活质量指数(Calgary Sleep Apnea Quality of Life Index,SAQLI),从主、客观方面对TCRF治疗OSAHS进行疗效评价。结果:术后6个月复查多导睡眠监测(polysomnography,PSG),50例患者中总有效43例,其中治愈19例,显效18例,有效6例,无效7例,总有效率86.0%。手术前后AHI平均值分别为45.20+20.50和26.50+30.15,LSaO2平均值分别为0.70+0.24和0.83+0.10。Epworth嗜睡程度评分由术前9.4+5.2下降至术后4.0+3.3,SAQLI总分从术前3.9+1.0提高到术后4.7+1.1,差异均有统计学意义(P值均<0.05)。结论:TCRF是治疗OSAHS的有效方法,可提高OSAHS患者的生活质量。

Objective： To determine the efficacy of temperature- controlled radio-frequency ablation （TCFR） for obstructive sleep apnea hypopnea syndrome （OSAHS） in adult. Methods： Some objective and subjective indexes of fifty patients with OSAHS were determined before and after TCRF treatment. A full-night polysomnography examination was performed on all patients. The Epworth sleepiness scale （ESS） and the Calgary sleep apnea quality of life index （SAQLI） were assessed before and six months after operation. Results： Of them, 19 cases were cured, 18 cases were significantly improved, 16 cases were improved, and 7 cases were not improved. The mean apnea hypopnea index （AHI） decreased from（45.2 ＋ 20.5）/h to （26.5 ＋ 30.2）/h and the mean lowest arterial oxygen saturation （ LSaO2 ） increased from（0.7 ＋0.1） to （0.8＋0.1）. The ESS decreased from （9.4＋5.2） to （4.0＋3.3） and the SAQLI increased from （3.8 ＋ 1.0） to （4.8 ＋ 1.1）. All the above differences were significant （ P 〈 0.05）. Conclusion： TCFR is an effective treatment for OSAHS and can improve the health-related quality of life.