BQ123抑制低温诱发肺动脉高压肉鸡的肺小动脉肌型化

BQ123 Inhibited The Muscularization of Nonmuscular Pulmonary Artery Induced by Low Ambient Temperature in Broiler

本试验用高选择性内皮素A受体拮抗剂BQ123处理低温肉鸡的方法,通过动态观察肺动脉压及肌型、部分肌型及非肌型肺小动脉数量的变化,探讨内源性内皮素在肺血管重塑中的作用。结果显示:30日龄时,低温组平均肺动脉压极显著高于常温组、低BQ123组及高BQ123组(P<0.01);低温组肌型及部分肌型肺小动脉的占位比均极显著高于常温组、低BQ123组及高BQ123组(P<0.01);低温组非肌型肺小动脉占位比极显著低于常温组、低BQ123组和高BQ123组(P<0.01),高BQ123组显著高于低BQ123组(P<0.05)。结果表明,BQ123可明显抑制低温肉鸡肺动脉高压和非肌型肺小动脉的肌型化的发生发展,因此认为内源性ET在低温诱发肺动脉高压肉鸡肺血管重塑的发生发展过程中起重要作用。

BQ123,a selective endothelin（ET）A-receptor antagonist,was used to treat broilers. This study investigated the effects of ET on the museularization of nonmuseular pulmonary artery in pulmonary hypertension（PH）induced by low ambient temperature. The results showed as follows：the mPAP of low temperature group （LT） was obviously highly than that of control group（CG）, low BQ123 group（LBQ123）and high BQ123 group（HBQ123）（P〈0.01）at 30 days age;MA% and PMA% of LT were obviously greater than that of CG,HBQ123 and LBQ123（P〈0.01）at 30 days age;NMA% of LT were obviously smaller than that of CG,LBQ123 and HBQ123 （P〈0.01） at 30 days age, It was concluded that BQ123 could significantly inhibit the museularization of nonmuseular pulmonary artery induced by low ambient temperature in broilers, Therefore ET played an important role in the development of the museularization of nonmuseular pulmonary artery of PH broilers induced by low ambient temperature.