摘要
对腺病毒的结构、转录和复制特性进行了较全面的介绍,回顾了腺病毒载体的发展历程,同时对各种动物腺病毒的现状进行了描述。进一步分析了腺病毒载体易于构建和操作、宿主范围广、感染性强等特性的分子机制。因其具有广泛的组织亲和性,腺病毒成为表达和传递治疗基因的主要候选者。随着动物腺病毒载体的发展,它将在控制人和动物传染性疾病,特别是病毒性传染病以及人类的基因治疗中发挥越来越重要的作用。
It is reviewed the structure, transcription and replication of adenovirus. It also looks back the development of adenovirus vector, describes all kinds of animal adenoviruses, and analyzes the molecular mechanism of easy manipulation, wide host spectrum, and strong infection characteristics of adenovirus vector. Adenovirus is the main candidate for expressing and delivering therapy genes because of its intensive tissue tropism. With the development of adenovirus vector, the adenovirus will play a more and more important role in controlling human and animal diseases, especially viral diseases as well as in human gene therapy.
出处
《天津农学院学报》
CAS
2007年第2期48-51,共4页
Journal of Tianjin Agricultural University
关键词
腺病毒
载体
结构
adenovirus
vector
structure
