辛伐他汀治疗急性心肌梗死的临床疗效观察

The clinical efficacy of simvastatin in the treatment of acute myocardial infarction

目的探讨辛伐他汀治疗急性心肌梗死（AMI）的临床疗效。方法将确诊为AMI的患者156例随机分为2组,均给予常规治疗,治疗组84例同时给予辛伐他汀20-40 mg,1次/天,口服。观察两组患者的存活出院率,并随访1年。结果治疗组存活出院率、1年存活率明显高于对照组（P〈0.05）,再次心性事件发生率明显低于对照组（P〈0.05）。结论辛伐他汀治疗AMI能够改善预后,疗效满意。

Objective To investegate the clinical efficacy of simvastation in patients with acute myocardial infarction （AMI）. Methods 156 patients with AMI who received the conventional therapies, such as thrombolysis, antiplatelet and antianginal therapies were randomized into two groups,and 84 patients in the treatment group were given simvastatin 20 -40 mg,po,qd,at the same time. Results The rate of survival leave hospital and that of the survival after one year were higher （ 77.38% vs 62.50% , P 〈 0. 05 ; 81.67% vs 57. 14% ,P 〈 0. 01 ） and the heart ocurrence rate was lower （ 60. 00% vs 80. 95% ,P 〈 0. 05 ） in one year in the treatment group than that in the control group. Conclusion The clinical efficacy of simvastatin on AMI was satisfactory.