先天性胆道闭锁患儿心肌组织的电镜观察

Ultrastructural study on myocardial tissue in a case of congenital biliary atresia

利用透射电镜观察一例先天性胆道闭锁(biliary atresia,BA)患儿心肌组织的超微结构,发现心肌细胞内肌原纤维萎缩,排列紊乱,部位肌原纤维断裂。线粒体明显增生,空泡化现象或基质水肿并出现羊毛样致密物(woolydensities)常见。闰盘少又残缺。此结果说明,BA引起的高胆红素血症及高胆汁酸血症可严重损伤心肌细胞。

The uhrastructure of the myocardial tissue of a child with congenital biliary atresia was studied by electron microscopy. The myocardial fibrillae were atrophic and disorderly arranged. Some heaps of myolysis were encountered. Mitochondria proliferated markedly, some of them were vacuolated or contained wooly densities in their matrix. The intercalated discs were rare and incomplete. This findings indicate that hyperbilirubinemia and high serum bile acid level caused by biliary atresia can seriously damage the myocardial cells.