摘要
以鬼臼毒为原料,经C-4羟基保护、酯羰基在低温下的烯醇化、在C-2位进行β-氯代和C-4去保护等4个步骤制备了化合物2β-氯鬼臼毒,给出了其IR、1HNMR和MS谱数据。
β chloropodophyllotoxin was prepared starting from podophyllotoxin in four steps which consisted of protecting hydroxy at C 4,enolization of ester carbonyl under low temperature,chloration at C 2 and deprotection at C 4,whose data of IR, 1HNMR and MS were also given.The stereochemistry of the product was discussed.
出处
《西北师范大学学报(自然科学版)》
CAS
1997年第2期45-47,共3页
Journal of Northwest Normal University(Natural Science)
基金
甘肃省教委科研资助
关键词
鬼臼毒
2β-氯鬼臼毒
抗肿瘤活性
抗肿瘤药
podophyllotoxinpicropodophyllotoxin2 β chloropodophyllotoxinstereoche mistryantitumor activity