期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

慢性神经病理性痛对小鼠细胞免疫功能的影响 被引量：4

The influence of chronic neuropathic pain on cellular immune function of mice
下载PDF
导出
摘要 目的探讨慢性神经病理性痛对小鼠细胞免疫功能的影响。方法在通过结扎小鼠单侧胫神经和腓总神经建立慢性坐骨神经病理性疼痛模型的基础上,利用淋巴细胞增殖试验(MTT法)和酶联免疫吸附试验(ELISA)动态观察慢性神经病理性疼痛对T淋巴细胞增殖活性以及血清中肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的影响。结果神经病理性疼痛模型小鼠的T淋巴细胞增殖活性明显高于假手术组及对照组,外周血液中的TNF-α和IL-6亦明显高于假手术组及对照组。结论小鼠在慢性神经病理性疼痛状态下细胞免疫功能明显增强。 Objective To explore the influence of chronic neuropathic pain on cellular immune function of mice models. Methods The mice models were established by ligating tibeal nerve and common peroneal nerve on one side, and the influence of chronic neuropathic pain on cellular immune function and tumor necrosis factor- α （TNF-α ） and interleukin-6 （IL-6） was observed with lymphocyte cell increase experiment （MTT method） and enzyme linked immunosorbent assay （ELISA）. Results The increased reactivity of T lymphocyte of the model group was significantly higher than that of the sham group and the control group. At the same time, content of TNF-α and IL-6 in blood of the model group also increased. Conclusion Cellular immune function of mice is increased in the state of chronic neuropathic pain.
作者 邵玲巧 袁育康 王军阳 任会勋
机构地区 西安交通大学医学院免疫学与病原生物学系
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2007年第3期252-254,共3页 Journal of Xi’an Jiaotong University（Medical Sciences）
关键词 神经病理性痛 肿瘤坏死因子 白介素-6 T淋巴细胞 chronic neuropathic pain tumor necrosis factor-α interleukin-6 T lymphocyte
分类号 R392.32 [医药卫生—免疫学]
  • 相关文献

参考文献6

  • 1Seltzer Z,Dubner R,Shir Y,et al.A novel behavioural model of neuropathic pain disorders produced in rats by partial sciatic nerve injury[J].Pain,1990,43:205-218.
  • 2Decosterd I,Woolf CJ.Spared nerve injury an animal model of persistent peripheral neuropathic pain[J].Pain,2000,87:144-160.
  • 3Jasmin L,Kohan L,Franssen M,et al.The cold plate as a test of nocieceptive behavirors:description and application to the study of chronic neuropathic and inflammation pain models[J].Pain,1998,75:334-388.
  • 4马青平.新镇痛药的研制[J].中国疼痛医学杂志,1998,4(2):120-124. 被引量：6
  • 5宋学军.神经病理性疼痛的动物模型和分子机制[J].江苏临床医学杂志,2002,6(5):388-391. 被引量：5
  • 6赵峰,戴红,郑泓溶,熊开宇.中枢性疼痛机制的研究进展[J].中华物理医学与康复杂志,2003,25(5):311-314. 被引量：3

二级参考文献50

  • 1[1]Abdulla FA,Smith PA.Axotomy- and autotomy-induced changes in the excitability of dorsal root ganglion neurons[J].J Neurophysiol,2001,85:630
  • 2[2]Abdulla FA,Smith PA.Axotomy- and autotomy-induced changes in Ca2+ and K+ currents of rat dorsal root ganglion neurons[J].J Neurophysiol,2001,85:644
  • 3[3]Ambron RT,Walters ET.Priming events and retrograde injury signals[J].Mol Neurobiol,1996,13:61
  • 4[4]Ambron RT,Zhang XP,Gunstream JD,et al.Intrinsic injury signals enhance growth,survival,and excitability of Aplysia neurons[J].J Neurosci,1996,16:7469
  • 5[5]Bennett GJ,Xie YK.A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man[J].Pain,1988,33:87
  • 6[6]Devor M.The pathophysiology of damaged peripheral nerves[M].In:Text Book of Pain,edited by Wall PD,Melzack R.3rd Ed.London,1994,79
  • 7[7]Gunstream JD,Castro GA,AND Walters ET.Retrograde transport of plasticity signals in Aplysia sensory neurons following axonal injury[J].J Neurosci,1995,15:439
  • 8[8]H?kfelt T.Molecular signal responsible for the reorganization of the synaptic circuitry of the dorsal horn after peripheral nerve injury:the mechanisms of tactile allodynia[M].In:D.Borsook (Ed.),Mol Neurobiol of Pain,Progress in Pain Research and management,Vol.9,IASP Press,Seattle,1997
  • 9[9]H?kfelt T,Zhang X,Xu ZQ,et al.Phenotype regulation in dorsal root ganglion neurons after nerve injury:focus on peptides and their receptors[M].In:Borsook D (Ed.),Mol Neurobiol of Pain,Progress in Pain Research and management,Vol. 9,IASP Press,Seattle,1997
  • 10[10]Hu SJ,Xing J.An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat[J].Pain,1998,77:15

共引文献11

同被引文献82

引证文献4

二级引证文献9

西安交通大学学报（医学版）
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部