液相催化加氢制备对氨基苯乙醚

Preparation of p-Ethoxyaniline by Liquid Phase Catalytic Hydrogenation

研究了以对硝基苯乙醚为原料、骨架镍为催化剂、工业甲醇为溶剂,液相催化加氢制备对氨基苯乙醚的还原反应。结果表明:以筛孔0.125mm的三元阮内镍催化剂较好,并可循环套用5次;反应温度90～105℃,反应压力1.5MPa,溶剂的体积与溶质的物质的量的比为100mL/0.2mol,搅拌速度800r/min。产品纯度≥99.0%,收率≥90.5%。相比硫化碱还原老工艺具有收率高、产品质量好、污染小等优点。

Reduction reaction in preparation of p-nitrophenetole by liquid phase catalytic hydrogenation is studied, with p-ethoxyaniline as raw material, Rancy-Ni as catalyst and industrial methanol as solvent. The optimal conditions are determined as follows:reaction temperature 90-105 ℃, reaction pressure 1.5 MPa, and ratio of solvent to reactant 100 mL/0.2 mo1.Under these conditions the product is 99.47% in purity and 91.11% in yield .