大肠癌和大肠腺瘤组织中的P16、Rb基因蛋白的表达及其意义

THE EXPRESSION AND SIGNIFICANCE OF P16,Rb ONCOPROTEINS IN THE CARCINOMA AND ADENOMA OF COLORECTUM

该文应用免疫组化法研究大肠癌和大胸腺癌组织中P16、Rb基因蛋白的表达及意义。32例大肠癌P16、Rb阳性病例率分别为34．3％和40．6％，40例腺瘤则分别为72．5％和37．5％。P16阳性病例率在大肠癌各病理组织类型中无明显差异，但Rb阳性病例率高分化腺癌较明显低于其他类型大肠癌（P＞0.05）；ATP（0～＋）级腺瘤P16阳性病例率明显高于ATP（＋＋～＋＋＋）级腺癌（P＜0.01）;ATP（O～＋）级腺瘤Rb阳性病例率较明显低于ATP（＋＋～＋＋＋）级脉瘤（P＞0.05）.揭示P16、Rb蛋白可能与大肠癌发生发展、生物学行为等有较密切关系。

The expressions and biological significances of P16, Rb oncoproteins were investigated by ABC immunohistochemical method in 32 cases of colorectal carcinoma and 40 cases of colorectaI adenoma. The positive case rate ofP16, Rb in colorectal carcinomas was 34. 3 % and 40. 6 % respectively, and in colorectal adenomas was 72. 5 % and37: 5 % respectively. The correlations were not found among the expressions of P16, Rb oncoproteins and the pathoIogical types of colorectal carcinoma. The positive case rate of P16 oncoprotein was significantly higher in adenomaswith (0~ + ) grade of atypical hyperplasia (ATP) than in ones with (+ + ~ + + + ) grade of ATP (P< 0. 01).The positive case rate of Rb oncoprotein was higher in adenoma with (+ + ~ + + + ) grade of ATP than in oneswith (0~ + ) grade of ATP (P>0. 05) These results suggested the correlations might exist among the expressionsof P16, Rb oncoproteins and the carcinogenesis, development, biological behaviors of the colorectal carcinoma.