氨基酸转运载体研究进展

Research Progress on Amino Acid Transporters

氨基酸转运载体是介导氨基酸跨膜转运的膜蛋白,在氨基酸营养机体细胞和神经调节过程中起着重要作用;而且,其功能异常会导致严重的氨基酸吸收和代谢障碍性疾病,也具有重要的病理学意义。本文就近年来关于中性氨基酸、酸性氨基酸和碱性氨基酸转运载体家族成员及其组织分布、分子生物学特征、生理功能和病理学意义等研究进展进行了综述。

Amino acid transporters are the membrane proteins which mediate the transport of amino acids across the plasma membrane. They are required not only to supply cells with amino acids for cellular nutrition but also to fulfill specialized cellular functions. Their functional abnormity can induce the severe disorder of amino acids absorbability and metabolism. This article mainly discussed members of neutral, acidic and basic amino acid transporters and their tissue distribution, biological characteristics and physiological and pathological roles.