周围动脉粥样硬化闭塞症胰岛素抵抗、内皮素、血管紧张素Ⅱ相互关系的研究

STUDY ON THE INTER-RELATIONSHIP AMONG INSULIN-RESISTANCE,ENDOTHELIN AND ANGIOTENSIN-I IN PERIPHERAL ARTERIO-ATHEROSCLEROTIC OCCULSIVE DISEASE (PAAO)

为探讨周围动脉粥样硬化闭塞症的胰岛素抵抗、内皮素、血管紧张素Ⅱ之间的相互关系,作者对32例本病患者进行糖耐量试验前后血糖、胰岛素水平测定,并计算其曲线下面积,同时采用放射免疫方法测定空腹血浆血管紧张素Ⅱ、内皮素含量,并分别与胰岛素及其曲线下面积作相关分析。结果表明,周围动脉粥样硬化闭塞症患者存在胰岛素抵抗,且糖耐量试验前后胰岛素水平及其曲线下面积均与血管紧张素Ⅱ、内皮素呈正相关系。提示胰岛素抵抗、血管紧张素Ⅱ、内皮素之间相互影响、相互促进、共同参与周围动脉粥样硬化闭塞症的形成和发展。

To study the inter-relationship among insulin-resistance, endothelin and angiotensin- in Ⅱ PAAO patients, the authors performed glucose and insulin level measarements during glucose tolerance test and calculate the respective area under curve (AUC). Fasting Plasma angiotensin Ⅱ and endothelin contents were deterrained with RIA;linear correlative analysis was done with respect to insulin levels and AUC. The results revealed increased insulin resistance in PAAO patients; the insulin levels and AUC during glucose tolerance test were positively correlatcd with angiotensin Ⅱ and endothelin contents. These 3 parameters seemed to be mutually influential and partici-pating in the pathogenesis of arterio-atherosclerosis.