叶酸对冠心病患者不对称二甲基精氨酸和同型半胱氨酸的影响

An Influence of Folic Acid on the Asymmetric Dimethylarginine and Homocysteine of the Patients with Coronary Heart Disease

目的探讨叶酸对冠心病患者不对称二甲基精氨酸(ADMA)和同型半胱氨酸(Hcy)的影响,为冠心病的治疗提供新的依据。方法冠心病患者70例,分为叶酸组36例,予以叶酸5mg,3次/日;非叶酸组34例,不加用叶酸;健康体检者22例为对照组。测定其血清ADMA、Hcy、VB12和叶酸以及血糖、血脂等。结果6个月后,叶酸组的血清叶酸由(8.26±3.03)μg/L增至(12.88±7.25)μg/L,Hcy由(32.91±16.06)μmol/L降至(23.55±6.01)μmol/L,前后比较均有显著性差异(P<0.05);而ADMA和VB12无显著变化(P>0.05)。结论补充叶酸能改善冠心病患者的低叶酸状态和高同型半胱氨酸血症,而对ADMA则无显著影响。

Objective To observe the influence of folic acid on asymmetric dimethylarginine（ADMA） and homocysteine（Hcy） of the patients with coronary heart disease. Methods The ADMA, Hcy, VB12, folic acid, total cholesterol, triglycerides, glucose were measured in serum of 36 cases with coronary heart disease who were given folic acid 5 mg three times a day（folic acid group）, 34 cases with coronary heart disease who were not given folic acid （ non - folic acid group） and 22 healthy subjects（ control group）. Results After six months in folic acid group the level of folic acid increased from （ 8.26 ± 3.03）μg/L to （ 12.88 ± 7.25）μg/L, Hcy from （32.91 ± 16.06）μmol/L to （23.55 -± 6.01）μmol/L, respectively（ P 〈 0.05）and ADMA and VB12 were not significantly different（ P 〉 0. 05） compared with those before supplement. Conclusion Supplemental folic acid may increase the serum level of folic acid and improve hyperhomoeysteineamia and have no effects on levels of ADMA of the patients with coronary heart disease.