ET RIA在出血性中风患者的临床应用

CLINICAL APPLICATION OF ET-RIA IN PATIENTS WITH HEMORRHAGIC CEREBRAL VASCULAR ACCIDENT

内皮素(Enaotnelin,ET)是一种具有强烈缩血管效应的多肽,本文研究应用放射免疫分析测定38例脑出血(ICH)患者血浆和32例蛛网膜下腔出血(SAH)患者血浆和脑脊液的ET含量,并分析ET与脑出血和SAH患者病情程度的关系。结果显示:(1)脑出血患者血浆ET含量测定显著高于对照组(p<0.01),以发病后8～14天最高,严重神经缺损的患者血浆ET水平明显高于轻型的患者。(2)SAH患者血浆和脑脊液中ET水平显著高于对照组(p<0.01),以发病后4～14天最高。结果表明,ET RIA是一项简易的检测方法,它对出血性脑血管病的诊断、病情观察和预后估计均有重要的临床意义,并提供一项新的诊断指标。

Endothelin is a potent vasoponstrictor polypeptide. To study the relation between ET levels and clinical condition of patients with intracerebral hemorrhage (ICH) and subarachnoid hemorrhage(SAH),we measured ET levels in plasma of 38 patients with ICH as well as in plasma/CSF of 32 patients with SAH by radioimmunoassay.The results showed that:① All plasma ET levels in the patients with ICH were significantly higher than those in the controls(p<0.01),plasma ET concentrations were hlgheston days 8 to 14 aftef the accideat. Levels in those patients with severe neurologie deficits were significantly higher than those with milder deficits. ②plasma and csf ET levels in patients with SAH were also significantly higher than those in the controls(p<0.01) and were highest on days 4 to 14 after the accident.Those results indicated that ET-RIA was a simple method to diagnoses and predict pnognosis in patients with ICH and SAH. Thus, it was of important clinical significance and could serve as a new diagnostie index.