肺癌及其癌旁组织中EGFR的表达及意义

EXPRESSION AND SIGNIFICANCE OF EGFR IN PRIMARY LUNG CARCINOMA AND THEIR ADJACENT TISSUE

应用Ｓ－Ｐ免疫组化法检测了７０例原发性肺癌及其癌旁组织的表皮生长因子受体（ＥＧＦＲ）表达，结果表明肺癌ＥＧＦＲ阳性率７７．１４％，ＥＧＦＲ阳性率及阳性程度与肺癌病理类型、肿瘤大小及是否发生淋巴结转移无相关性（Ｐ＞０．０５）。癌旁组织阳性率６８．２５％，增生组癌旁上皮细胞阳性率（８１．０３％）显著高于无增生组阳性率（４０．５４％）（Ｐ＜０．０５）。肺癌组织阳性率与增生组癌旁组织阳性率无统计学上的差异。认为ＥＧＦＲ在各型肺癌中的过度表达与肺癌的无限制生长有关，但不能作为肺癌恶性程度及预后的有效指标。ＥＧＦＲ过度表达在肺癌的发生中起重要作用，可能是肺癌发生的早期标志物。

We examined the expression of EGFR in 70 primary lung cancer and 63 paracarcinous tissue by using S P immuno histochemistry. Results:The positive rate of EGFR in lung cancer was 77.14%. The positive staining was located in cancerous cytoplasm as well as membrane. There was no statistical significance between EGFR expression and pathological types, tumorous size or lymph node metastasis respectively(P>0.05). The positive rate of EGFR in paracarcinous tissue was 68.25%. The positive staining was observed in of the ER the PR would be. They were not associated with sex. The high and the low positive levels of the ER and PR were used as deciding malignent degree of the tumors, evaluating prognosis and the choice indicators of endocrinotherapy.