N-异吲哚-1,3-二酮取代苯基-N’-苯甲酰基脲类衍生物的合成与除草活性

Synthesis and herbicidal activity of N-isoindoline-1,3-dione-substituted phenyl-N'-benzoyl ureas

为寻找高效、安全的除草活性化合物,以商品化除草剂丙炔氟草胺为先导化合物,设计并合成了11个N-异吲哚-1,3-二酮取代苯基-N’-苯甲酰基脲类化合物,其化学结构经IR1、H NMR、LC/MC和元素分析确证。初步生物活性测定结果表明,该类化合物对阔叶杂草具有较好的芽后除草活性,如5 a、5b、5 c、5 e、5 f、5g等化合物在75 g/hm2剂量下,茎叶处理对苘麻、藜、凹头苋等阔叶杂草的抑制率达80%以上。

In search of safer and more efficiency herbicidal compounds, flumioxazin was chosen as lead compound, and eleven N-isoindoline-1,3-dione-substituted phenyl-N＇-benzoyl ureas were designed and synthesized. Their structures were confirmed by IR, ^1H NMR, LC/MC and elemental analysis. Preliminary bioassay showed that most of title compounds had better herbicidal activity,for example,5a,5b,5c,5e,5f and 5g exhibited more than 80% inhibition to broad-leaved weeds, such as Abutilon theophrasti, Chenopo- dium album L. ,Amaranthus ascedense L. at 75 g/hm^2.