摘要
用免疫组化ＡＢＣ法和ＩＲＭＡ法分别检测了４２例乳腺癌和３０例良性乳腺病变患者组织中Ｈａ－ｒａｓ基因蛋白（ｒａｓＰ２１）的表达状况及血清ＣＡ１５－３值，结果恶性病变组织中ｒａｓＰ２１呈过度表达，ｒａｓＰ２１的表达与细胞的分化状态密切相关。不同淋巴结转移状况的乳腺癌患者，其血清ＣＡ１５－３差异呈显著性。ＣＡ１５－３水平的变化与ｒａｓＰ２１表达状况显著相关。提示血清ＣＡ１５－３水平为监测乳腺癌病情变化的良好指标，Ｈａ－ｒａｓ癌基因点突变的结果可能导致乳腺癌相关抗原的异常分泌。
Immunocytochemical analysis and immunoradiometic assay(IRMA) have been used to determine Ha ras oncogene expression in mammary tissues and circulating levels of CA15 3 in 46 patients with breast carcinoma and 36 patients with benign lesion. The results indicate that superlative ras P21 expression is observed among malignant mammary tissues and ras P21 expression has a good correlation with state of differentiation of breast tissues. Circulating CA15 3 lavels show a significant correlation with status of lymphatic matastases and expression of ras P21 in spectrum in patients with breast carcimona. It is suggested that serum CA15 3 may be a useful indicator in monitoring the clinical course of patients with breast carcinama and the result of Ha ras oncogene point mutation lead an course abnormal secretion of breast cancer associated antigen.
出处
《肿瘤研究与临床》
CAS
1997年第1期4-6,共3页
Cancer Research and Clinic
