苯乙酸溶解度测定及提取工艺研究

Study on the determination of PAA solubility and the extraction technology

为了提取6-氨基青霉烷酸（6．APA）、7-ADCA生产过程中产生的副产物苯乙酸，采用物理法测定了苯乙酸在水、水-乙醇、水-丙酮中的溶解度及其在水中的溶解速率，由此确定了水法多次提取的工艺方案。结果表明，在提取温度（60±2）℃，时间10～15min，水用量1500mL，提取次数3～4次时，苯乙酸收率为90．8％，纯度为99．3％。该法污染少、成本低，所得PAA产品质量好。

In order to extract the by-product phenyl acetic acid from the production process of 6-APA, 7-ADCA, the solubility of phenyl acetic acid in water, water-alcohol, water-acetone, and the solution rate in water were determined through the physical method. Accordingly, the technique of multi-extraction with water was determined. The experimental result indicated ： the yield of phenyl acetic acid was 90.8% and the purity was 99.3% ,when the extraction temperature is （60±2） ℃ ,the time is 10 ～ 15 min,the water amount is 1 500 mL, the extraction times is 3 ～ 4. The method had such advantages as low pollution,low costs, good quality of PAA product.