108例散发性戊型肝炎临床分析

The clinical analysis of 108 cases of sporadic hepatitis E infections

目的探讨散发性戊型肝炎的临床特点。方法对108例散发性戊型肝炎的分型、临床表现、血清生化及影像学等进行回顾性分析。结果重叠感染27例(25.0%);临床表现乏力(90.7%)、黄染(86.1%);60岁以上组血清谷丙转氨酶(ALT)、总胆红素(TBIL)与60岁以下组比较,差异有显著意义(P<0.05),重叠感染组血清TBIL、白蛋白(ALB)、γ-谷氨酸转肽酶(GGT)与单纯感染组比较,差异有显著意义(P<0.05);影像学肝脏弥漫性改变者68例(72.4%)。结论散发性戊型肝炎可与其他病毒性肝炎重叠感染,临床表现类似甲肝,老年患者、重叠感染者黄疸深、肝功能损害重,影像学改变与其他病毒性肝炎相似。

Objective To explore the clinical characteristics of sporadic hepatitis E. Methods The clinical and etiological types,clinical findings,serum biochemistries,and the image characteristics in 108 patients with sporadic hepatitis E were retrospectively analyzed. Results There were 27 patients（25.0%）with superinfections; The symptoms were impotence（90.7% ）and jaundice（86.1% ）;There was significant difference between the levels of ALT and TBIL in patients over 60-year-old and patients younger than 60-year-old（ P 〈 0.05）, and the level of TBIL, ALB and GGT were significant difference between the groups with superinfection and without; In the image characteristics the livers of 68（72.4 % ） patients showed diffuse changes. Conclusion Hepatitis E could superinfect with other hepatitis viruses, the clinical findings of hepatitis E were similar to that of hepatitis A; the jaundices in the old patients or the patients with superinfection were heavy, and their liver functions were heavily damaged; the image characteristics of hepatitis E were similar to that of other viral hepatitises.