黄酮类化合物研究(ⅩⅣ)——溴代异黄酮合成中的脱溴反应

Studies on Flavonoids(XIV)—— Debromination Reaction in the Synthesis of Bromoisoflavones

我们曾报道2-溴间苯二酚在BF_3催化下酰化时的脱溴现象。本文在以下述反应制备6-溴代异黄酮时发现4-溴间苯二酚脱溴现象更为显著。

6- Bromoisoflavone was prepared from 4- bromoresorcinol. Debromination reaction was found in the acylation of the starting material by using BF3 as catalyst, and a by-product, 4,6-dibro-moresorcinol, was also isolated. The reaction mechanism probably involves a bromonium ion.