^(99)Tc^m-ECDSPECT无创性脑血流量测定

Non-invasive Method for Quantification of Cerebral Blood Flow With ^(99)Tc^m-ECD SPECT

建立了一种使用99Tcm-ECD为显像剂,SPECT为显像装置,不抽血定量测定局部脑血流的方法。两个不同年龄组正常志愿者共20例,通过静脉弹丸式注射99Tcm-ECD,利用动态显像和感兴趣区勾画技术获取大脑半球及主动脉弓的时间放射性曲线,同时对曲线进行死时间校正,结合图形分析方法确立脑血流灌注率(Ku),大脑半球的灌注指数(BPI)获得平均脑血流量(mCBF)。结果显示:20例正常人的脑血流值分别为53.81±5.27 mL(100 g)-1.min-1(5～16岁),47.19±4.99 mL(100 g)-1.min-1(22～32岁),不同年龄组间有显著差异。本测定方法具有无创性,实际工作中的可操作性等特点,在临床上便于广泛开展,有一定应用价值。

A non-invasive method on quantification measurement of cerebral blood flow is established. Dynamic radionuclide angiography is performed in 20 normal youth subjects after bolus injection of ^99Tc^m-ECD into the right cubital vein of the right arm. ROIs are handdrawn over the aortic arch and bilateral brain hemispheres to produce time-activity curves respectively which are corrected by dead-time. The unidirectional influx rate （Ku）, brain perfusion index （BPI） are obtained by graphical picture analysis. And then BPI is converted to CBF. The mean value of the two groups CBF are 53.81±5.27mL（100g）^-1·min^-1 （5- 16 years）and 47.19±4.99 mL（100 g）^-1 · min^-1 （22-32 years）respectively. There is a significant deviation between the two groups. This method is non-invasive, operable and in favor of clinical application.