上皮型钙粘蛋白联合CA_(125)在子宫内膜异位症诊断中的价值

The role of E-cadherin and CA_(125) in the diagnosis of endometriosis

目的:探讨血清上皮型钙粘蛋白(E-cad)结合CA125在子宫内膜异位症诊断中的价值。方法:分别以酶联免疫法和放射免疫法检测子宫内膜异位症患者、对照组及正常人血清中E-cad和CA125的含量,并进行比较。结果:子宫内膜异位症组血清中E-cad含量较对照组和正常人均明显升高(P<0.05);单独依据E-cad诊断子宫内膜异位症的敏感性及特异性分别为79.3%及80.7%,单独依据CA125诊断子宫内膜异位症则分别为65.2%及51.9%,两者联合特异性明显提高,为84.1%。结论:血清E-cad含量在子宫内膜异位症患者明显升高;在子宫内膜异位症中血清E-cad较CA125特异性高,可望将其作为子宫内膜异位症的生物学标志分子之一。

Objective： To investigate the role of E - cadherin and CA125 in the diagnosis of endometriosis. Methods： The level of E - cadherin and CA125 in the serum of endometriosis patients were compared with that of the control group and normal group using the enzyme linked immunosorbent assay and radio - immunity. Results： The level of E - cad in serum of endometriosis patients was significantly higher than that of control and normal group. With the evaluation of E - cad, the sensitivity and specificity was 79. 3% and 80. 7%, respectively. While that of CA125 was 65. 2% and 51. 9%, respectively. Then, when both E -cad and CA125 were used to predict the diagnosis of endometriosis, the specificity increased to 84. 1%. Conclusion： In the serum of endometriosis, the level of E - cad is increased. The specificity of the increased level of serum E - cad is higher than that of CA125 to diagnose endometriosis. So, E - cad may become a biological maker of endometriosis.