利多卡因宫颈及宫腔内注射用于人工流产镇痛的临床探讨

Clinical investigation of effect of injection of lidocaine into the cervix and uterine cavity on artificial abortion

目的:探讨利多卡因宫颈及宫腔内注射用于人工流产镇痛的临床效果。方法:将符合要求并自愿接受人工流产手术的早孕患者300例随机分为三组:利多卡因组(130例)及异丙酚组(90例)分别采用利多卡因宫颈宫腔联合注射及异丙酚静脉注射用于人工流产镇痛,对照组(80例)不采取任何镇痛措施,观察每组患者镇痛有效率、宫颈松弛率及人工流产综合反应等并发症发生率等指标。结果:利多卡因组的镇痛有效率、宫颈松弛率均显著高于对照组(100%VS15.0%,P<0.01;89.2%VS 10.0%,P<0.01),人工流产综合反应等并发症发生率显著低于对照组;利多卡因组的镇痛有效率、人工流产综合反应等并发症发生率与异丙酚组无显著性差异,而宫颈松弛率显著高于异丙酚组。结论:利多卡因宫颈及宫腔内注射是一种既安全有效又简单方便的人工流产镇痛方法,值得临床推广应用。

Objective： To investigate the clinical effect of injection of lidocaine into the cervix and uterine cavity on artificial abortion. Methods： 300 pregnant women who meet the basic requirements and are willing to undergo artificial abortion were recruited. They were divided into three groups： Lidocaine group （ 130 cases） ： injection of lidocaine into the cervix and uterine cavity prior to artificial abortion; Propofol group （90 cases） ： intravenous injection of propofol prior to artificial abortion; Control group （80 cases） ： no analgesic measures were adopted. Observation indicators included the effectiveness rate of analgesic and the spontaneous dilated rate of cervical canal and the incidence of complications such as artificial abortion syndrome, et al. Results ： The effectiveness rate of analgesic and the spontaneous dilated rate of cervical canal in Lidocaine group were significantly higher than that in control group （ 100% vs 15. 0%, P 〈 0. 01 ; 89. 2% vs 10. 0%, P 〈 0. 01 ） ; The incidence of complications such as artificial abortion syndrome in lidocaine group was significantly lower than that in control group; The spontaneous dilated rate of cervical canal in lidocaine group were significantly higher than that in propofol group. Conclusion： The injection of lidocaine into the cervix and uterine cavity prior to artificial abortion is both safely effective and highly convenient and deserves clinical generalization.