2001～2005年湖北省围生儿出生缺陷监测资料分析

Analysis of Surveillance of Birth Defect on Perinatal Fetuses in Hubei Province during 2001-2005

目的 了解湖北省围生儿出生缺陷发生情况及影响因素。方法 在全省出生缺陷监测医院出生的妊娠满28周以上死胎、死产和活产中。连续监测2001～2005年围生儿出生缺陷的发生情况。结果 2001～2005年全省围生儿平均出生缺陷发生率为107．39／万，与2001年（81．07／万）比较，出生缺陷发生率明显上升（χ^2=39．505P〈0．001）。城乡出生缺陷发生率无显著性差异，但男女出生缺陷发生率存在明显差异，男童明显高于女童（χ^2=15．974P〈0．001）。围生儿出生缺陷的主要类型分别为唇裂、多指（趾）、神经管畸形、脑积水。结论 大力开展围生儿出生缺陷监测与干预工作，能有效降低围生儿出生缺陷发生率。

Objective To analyze the prevalence and factors of birth defect on perinatal fetuses in Hubel province. Method The prevalence of birth defect on perinatal fetuses delivered in 28 weeks or more was analyzed in Hubei surveillance hospital of birth defect during 2001 - 2005 year. Results The prevalence rate of birth defect on perinatal fetuses from 2001 to 2005 year was 107.39 per 10 000,and increased significantly than that in 2001 year 81.07 per 10 000 （ χ^2 = 39. 505 P 〈 0. 001 ）. The prevalence rates between urban and suburb were no significance, but those between male and female were significant（ χ^2 = 15. 974 P 〈0. 001 ）. The leading birth defects were cheileschisis,pelydactylia,nevous deforation and congenital hydrocephalus accordingly. Conclusion The surveillance and intervention program of birth defect shall be performed to decrease preference of birth deformation on perinatal fetuses.