骨松Ⅱ号对去卵巢兔骨代谢影响的骨计量学研究

Histomorphometric Study on the Effect of Gusong Ⅱ on Bone Turnover in Ovariectomized Rabbits

运用骨计量学观察了中药膏极Ⅱ号对兔切除卵巢诱导的骨质疏松症实验模型的影响，并与尼尔雌醇进行对照。结果显示：骨松Ⅱ号组与尼尔雌醇组在BV／TV、OV／BV、OBI、dLs／BS和BFR（T）等参数方面明显高于造模组和／或正常对照组，骨松Ⅱ号组OV／BV、OB％以及OBI等参数较尼尔雌醇级明显升高。提示：骨松Ⅱ号能增加成骨细胞数量，以产生较多骨质，使骨疏松症模型兔的骨代谢恢复正平衡，达到防治骨质疏松症的目的，其作用一定程度上优于尼尔雌醇。

The effects of Gusong Ⅱon experimentalpostmenopausal osteoporosis in ovariectomized New Zealand white rabbits were assessed histomorphometrically and compared with that of nylestriol. The results demonstrated that BV/TV, OBI,dLs/BS and BFR increased in both group A (OVXGusong Ⅱ) and group D (OVX-nylestriol) as compared with group B (OVX) and/or group C (Sham). Group A showed a significant increase of OV/BV, OB% and OBI as compared with group D. It indlcated that Gusong Ⅱcan stimulate the recruitment and/or proliferation of osteoblasts to produce more bone matrix, converting the bone turnover of OVX rabbits to a positive balance. This effect may be superior to that of nylestriol to some extent.