移植排斥反应中趋化因子及其受体表达的研究进展

Expression of chemokines and chemokine receptors in organ-graft rejection:recent progress

器官移植术后急、慢性排斥反应是导致移植物功能丧失的重要原因之一。趋化因子在器官移植早期表达异常活跃.它们特异性募集T细胞和抗原提呈细胞到移植组织内,激发并加剧炎症发展,致使移植物功能损害。因此.动态监测趋化因子及其受体的表达状况可成为判断急、慢性排斥反应发生的重要依据;筛选出一个或多个特异性趋化因子或受体作为抗排斥治疗的新靶点对提高器官移植术后疗效有很重要的意义。本文就近年来这一领域的研究进展作一综述。

Acute and chronic graft rejection are the major factors leading to graft non-function. There is an active expression of chemokines early after transplantation. They recruit T cells and antigen presenting cells selectively to the graft,leading to inflammatory reaction and finally to graft non-function. Accordingly,monitoring the expression status of chemokines and their receptors regularly may help to the diagnose rejection. To determine one or more chemokines or their receptors as the new targets for anti-rejection therapy will be of great clinical significance. This review focuses on the research progression in the above areas.