期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

妊娠期糖尿病患者血浆脂联素与瘦素的关系研究

Related Study of Adiponectin and Leptin Level in Plasma with Gestational Diabetes Mellitus
下载PDF
导出
摘要 目的探讨脂联素、瘦素与妊娠期糖尿病的关系.方法妊娠期糖尿病(GDM)患者与正常对照组各40例,采用体外放射免疫分析方法检测其血浆脂联素、瘦素、血糖及胰岛素水平,同时测身高、体重,计算体重指数(BMI)和胰岛素抵抗指数(HOMA-IR).结果经对数转化后的血浆脂联素、瘦素浓度在GDM组明显低于对照组,有显著性差异.结论瘦素与脂联素呈正相关,检测瘦素和APN预测GDM的进展和预后. Objective To explore the relation ship between adiponectin and leptin levels of patients and the gestational diabetes mellitus. Methods RIA was used to examine adiponeetin and leptin in 40 patients with each subjects. Meanwhile plasma levels of insulin, glucose, height, weigh, body mass index and HOMA - IR were measured and calculated. Results The lg of adiponectin and leptin in plasma from the gestational diabetes mellitus were significantly lower than that in normal subjects. Conclusion Adiponectin and leptin will play an important role in monitoring the patients with GDM.
作者 朱高红 陈玲 段炼
机构地区 昆明医学院第一附属医院核医学科 保山市人民医院 鹤庆县人民医院
出处 《昆明医学院学报》 2007年第3期87-89,共3页 Journal of Kunming Medical College
关键词 脂联素 妊娠期糖尿病 瘦素 Adiponectin Gestational diabetes mellitus Leptin
分类号 R714.256 [医药卫生—妇产科学] R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献6

  • 1KUHL C.Etilolgy and pathogenesis of gestational diabetes[J].Diabetes Care,1998,21(suppl 2B):19-26
  • 2杜同信,王自正,王书奎,马建华,陶晓军.2型糖尿病患者胰岛素抵抗与脂联素、瘦素关系的探讨[J].放射免疫学杂志,2005,18(5):321-322. 被引量：2
  • 3YAMAUCHI T,KAMON J,ITO Y,et al.Cloning of adiponectin receptors that mediate antidiabetic metabolic effects[J].Nature,2003,423:762-769
  • 4HOTTA K,FUNAHASHI T,BODKIN.Circulating concentrations of the adipocyte protein are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys[J].Diabetes,2001,50(5):1126
  • 5谢蓓,刘之武.瘦素的研究进展[J].标记免疫分析与临床,2004,11(3):180-182. 被引量：2
  • 6FESTA A,SHNAWA N,KRUGLUGER W,et al.Relative hypoleptinaemia in women with mild gestational diabetes mellitus[J].Diabet Med,1999,16(8):656-62

二级参考文献17

  • 1Tobe K, Ogura T, Tsukamoto C, et al. Relationship between serum leptin and fatty liver in Japanese male adolescent university students leptin and fatty liver in Japanese male adolescent university students[J]. Am J Gastroenterology, 1999, 94 (11): 3328 -3
  • 2Faggioni R, Jones - Carson J, Reed D A, et al. Leptin - deficient (ob/ob) mice are protected from T cell - mediated hepatotoxicity:role of tumor necrosis factor alpha and IL - 18[J]. Proc Natl Acad Sci USA, 2000, 97(5) :2367 - 2372.
  • 3O'Donnell C P, Schaub C D, Haines A S, et al. Leptin prevents respiratory depression in obesity [J]. Am J Respir Crit Care Med, 1999, 159(5 Pt 1):1477-84.
  • 4Williams G, Harrold J A, Cutler D J, et al. The hypothalamus and the regulation of energy homeosatsis [J]. Proc Nutr Soc,2000, 59 (3) :385 - 396.
  • 5Konturek P C, Brzozowski T, Sulekova Z, et al. Role of leptin in ulcer healing [J].Eur J Pharmacol, 2001, 23:414(1):87-97.
  • 6Azuma T, Suto H, Ito Y, et al. Gastric leptin and Helicobactor pylori infectin[J]. Gut, 2001, 49(3) :324 - 329.
  • 7Vecchion C, Maffei A, Colella S, et al, Leptin effect on endothelial nitric oxide is mediated through Akt - endothelial nitric oxide synthase phosphorylation pathway [J]. Diabetes, 2002, 51 (1):168 - 173.
  • 8Kang S M, Kwon H M, Hong B K, et al. Expression of leptin receptor(Ob- R)in human atherosclerotic lesions: potential role in intimal neovascularization[J]. Yonsei Med J, 2000, 41 (1): 68 -75.
  • 9Leptin E, Hurt-Camejo E, Wiklund O, et al. Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes. Atherosclerosis. 2003, 166:387.
  • 10Fasshauer M, Kralisch S, Kliver M, et al. Adiponectin gine expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2003, 301:1045.

共引文献2

昆明医学院学报
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部