CT引导下射频消融治疗不能切除的原发性肺癌22例

CT-guided radiofrequency ablation for unresectable primary lung cancer in 22 patients

目的：探讨CT引导下射频消融治疗不能切除的原发性肺癌的临床效果和安全性．方法：对不能切除的原发性肺癌22例27个肿瘤进行多电极高温射频治疗，观察患者术前及术中无创血压、脉搏和周围血氧饱和度，治疗后肝肾肺功能，CT扫描肿瘤组织低密度影和肿瘤体积的变化以及术后5a生存率．结果：射频消融治疗中患者血压、脉搏和周围血氧饱和度无统计学改变；治疗后肝肾肺功能无统计学改变；治疗后1 mo内肿瘤体积增大，治疗后3 mo CT扫描显示在27个肿瘤中，肿瘤完全消失（CR）14个（衰退100％）；肿瘤缩小（Pra）8个（衰退80％-100％）；肿瘤缩小（PRb）4个（衰退50％-80％），肿瘤缩小（NR）1个（衰退小于50％）．肿瘤内低密度影3 moI型1个；1I型12个；Ⅲ型14个．5a生存率为40．91％（9／22）．结论：射频消融治疗不能切除的原发性肺癌效果良好、创伤小，是对不能切除的原发性肺癌潜在补充治疗．

AIM： To explore the clinical effects and safety of CT-gnided radiofrequency ablation in the treatment of unresectable primary lung cancer. METHODS： Twenty-two patients with 27 unresectable primary lung cancer were treated with RF-2000. Non-invasive blood pressure, pulse rate and oxygen saturation were monitored during the treatment; the variations of the liver, lung and renal functions after treatment were examined ; the changes of tumor bulk and tumor low-density shadow was scanned by CT. 5-year follow-up was conducted. RESULTS： The blood pressure, pulse rate and oxygen saturation did not change signifi- candy during the treatment; the changes of the liver, lung and renal functions were not significant statistically. One month after treatment, the tumor bulk was enlarged; 3 months after treatment, of the 27 tumors, 14 showed CR （100% regression）, 8 PRa （80% - 100% regression ） , 4 PRb （ 50% - 80% regression ） , and 1 NR （ less than 50% regression） ; tumor low-density shadow on CT scan at post-treatment 3 months revealed I type （ less than 50%） in 1, lI type （50% -80%） in 12, III type （more than 80%） in 14. 5-year survival rate was 40. 91% （9/22）. CONCLUSION： CT-gnided radiofrequency ablation was demonstrated effective and safe in treating unresectable primary lung cancer, and the trauma was recognized minimal. So it is a potential complementary therapy for unresectable primary lung cancer.