克拉霉素对晚期胃癌的治疗作用

Curative Effect of Clarithromycin in Treating the Stomach Neoplasms

目的探讨克拉霉素对晚期胃癌的治疗作用。方法将66例晚期胃癌患者随机分为两组,对照组(n=34)给予奥沙利铂+5-氟尿嘧啶+亚叶酸钙方案进行化疗,观察组(n=32)在对照组化疗方案的基础上给予克拉霉素500mg早、晚餐前1h口服,连用7d。治疗1个疗程后对两组患者的疗效、毒副反应以及3年生存率进行比较。结果两组患者疗效及3年生存率间差别有统计学意义(P<0·05),而毒副反应间差别无统计学意义(P>0·05)。结论克拉霉素对晚期胃癌的化疗具有协同作用,能明显提高联合化疗的疗效,而不增加毒副反应。

Objective To explore the curative effect of clarithromycin to stomach neoplasms. Methods A total of 66 cases with stomach neoplasms were divided into two groups randomly ; The patients in the control group （ n = 34 ） were treated with oxaliplatin, 5 - Fu and calcium folinate ; and those in the trial group （ n = 32 ） were treated with the same remedy as the control in combination with clarithromycin 500 rag, taken orally 1 hour before breakfast and supper, for successive 7 days. After one course of treatment the curative effect, poison reaction and 3 - year survival time rates between two groups were compared. Results The differences in curative effect and 3 - year survival time rates between two groups were significant （ P 〈 0. 05 ）, but the difference in poison reaction between two groups was not significant （ P 〉 0. 05 ）. Conclusion Clarithromycin is a synergistic to chemotherapy for stomach cancer, and can improve the effect of unite chemotherapy, with no increase of the poison reaction.