室内装饰材料中甲醛的致突变作用研究

Study on the Mutagenicity of Formaldehyde in Indoor Decoration Materials

对不同浓度气态甲醛诱导昆明种小鼠骨髓嗜多染红细胞微核率进行了统计分析.将40只小鼠随机分成对照组和4,12,36 mg/m3剂量组,采用静式呼吸道染毒,连续染毒4d,每天6h,染毒结束后将小鼠处死,测定微核率.结果表明,中、高剂量组的小鼠骨髓微核率与阴性对照组比较有显著性差异(P<0.05);不同剂量组微核率经方差分析有显著性差异(P<0.01);经F检验,受试物剂量组之间无显著性差异(P>0.05),且雌雄两性微核率无显著性差异(P>0.05);环磷酰胺组(40 mg/kg Bw)微核率与阴性对照组同性别微核率相比,有显著性差异(P<0.01),且雌、雄两性微核率均无显著性差异.认为气态甲醛对小鼠有致突变作用.

Statistical analysis was done for the rate of bone marrow call micronucleus induced by different dose of formaldehyde. 40 mice were randomly divided into 5 groups , two of which was for control , and the other three were 4,12 and 36 mg/m^3 dose group respectively. The mice were killed after they were given inhalation exposure of formaldehyde in a peaceful environment for 4 days, 6 hours per day and then the rates of bone marrow cell micronucleus were measured. The results showed that there was a significant difference between high-middle dose groups and control group （P〈 0. 05）. Through statistical analysis different dose group had signifieam difference（P〈0. 01）. Compared with negative group the Cyclophosphamide（40 mg/kg Bw） group had significant difference（P〈0.01）, and the male and female had not significant difference. The results showed that formaldehyde might be of mutagenesis on mice.