CD44v6、CEA检测在癌性胸水患者中的临床应用

Clinical significance of CD44v6 and CEA mensurating in malignant pleural effusions

目的探讨CD44v6和CEA在胸腔积液性质鉴别诊断中的应用价值。方法选取65名胸腔积液患者,35例为恶性胸腔积液,30例为良性胸腔积液。抽取胸腔积液后采用ELISA法及化学发光方法检测CD44v6、CEA的含量。结果恶性胸腔积液中的CD44v6、CEA水平明显高于良性胸腔积液,差异有统计学意义。CD44v6的恶性胸腔积液诊断分界点为15.60ng/ml,敏感性为88.60%,特异性为80.00%。CEA的恶性胸腔积液诊断分界点为1.15ng/ml,敏感性为68.60%,特异性为63.30%。CD44v6+CEA联合检测的敏感性为88.60%,特异性为86.70%。结论CD44v6、CEA检测对良、恶性胸腔积液的鉴别诊断有一定的临床意义,两者联合检测可提高诊断的特异性。

Objective To explore the diagnostic value of CD44v6 and CEA in distinguishing malignant pleural effusion from benign one. Methods Sixty - five patients with pleural effusions were observed. Among them, 35 cases suffered from malignant pleural effusion and 30 suffered from benign one. The quantities of CD44v6 and CEA in the pleural effusion were tested by ELISA and chemistry luminescence technique. Results The levels of CD44v6 and CEA in malignant pleural effusion were clearly higher than that in benign pleural one, the difference had significant statistic meaning. The cutoff of CD44v6 was 15.60ng/ml, the sensitivity of CD44v6 examination was 88.60%, and the specificity was 80.00%. The cutoff of CEA was 1.15ng/ml, the sensitivity of CEA examination was 68.60%, and the specificity was 63.30%. The sensitivity of CD44v6 ＋ CEA was 88.60% , the specificity was 86.70%. Conclusions CD44v6 and CEA tests had certain clinical significance in the diagnosis of malignant and benign pleural effusions. CD44v6 allied CIgA test could improve specificity of diagnosing.