温度对生物组织模拟液光学特性影响的研究

Study of the Effect of Temperature on Optical Properties of Biological Tissue-simulating Phantom

采用牛奶作为生物组织的模拟液,研究温度变化对生物组织光学特性的影响。应用双积分球技术对牛奶在光波波长为1100-1700 nm、温度25-40℃范围内的光学参量进行了测量,分析光学参量随温度的变化规律。结果表明,温度对散射作用的影响比吸收作用更大,随温度的升高,约化散射系数具有明显减小的趋势。与25℃相比,40℃下的约化散射系数下降了约10%;而吸收率的变化趋势不明显且规律复杂。以上研究结果与公开发表的人体离体皮肤组织光学参量随温度变化的研究结果基本一致,从而为深入研究温度对生物组织光学测量的影响提供了理论和实践上的指导。

The effect of temperature on the optical properties of biological tissue has been studied by using milk as the simulation sample. Optical properties of milk at 1100-1700 nm were measured by using the double integrating sphere technology in the temperature range of 25 - 40 ℃. Then the rule of change of optical properties with temperature was analyzed. The results show that the effect of temperature on scattering is greater than absorption. Obvious decrease can be observed with increasing temperature in the reduced scattering coefficient, which decreases by 10 % at 40 ℃ compared to that at 25 ℃. And the change of absorptivity of milk with increasing temperature is small and complicated. The results were consistent with the reported results on the study of ex vivo tissue. This study provides valuable theoretical reference and practical experiences and leads to investigate the effect of temperature on optical properties of biological tissue.