含二茂铁基的取代缩氨基脲、取代缩氨基硫脲的合成和性质

The Syntheses and Properties of Substituted Semicarbazones and Thiosemicarbazones Containing Ferrocenyl Group

缩氨基脲、缩氨基硫脲既是很好的金属离子配体,又有很好的生物活性,如抗细菌、病毒、抗结核、抗麻疯病、抗风湿、抗嗜眠等,文献曾有一些报道。其中有些在结构上调整,引入二茂铁基,显示了一些特殊性质。本文在此基础上进一步合成了12个新型结构的含二茂铁基的缩氨基脲(或硫脲),对它们的性质作了初步研究。

This paper reports twelve new substituted semicavbazones and thiosemicarbazones which contain ferrocenyl group. All of these compounds are characterized on the basis of elemental analysis, IR and 1H NMR. A number of transition element (Cu, Co, Ni, Zn) complexes with thiosemicar-bazone prepared from formylferrcene and thiocarbohydrazide have been prepared and characterized. Using some of these compounds and Cu(Ⅱ) complexes, we have observed the bacteriostatic activity of them. It is shown that those compounds have significant bacteriostasis on Staphylococcus autreus, Bacillus Subtilis and Escherichia Coli