葡萄胎危险因素的1∶2配比病例对照研究

A 1∶2 MATCHED CASE-CONTROL STUDY ON RISK FACTORS OF HYDATIDIFORM MOLE

[目的]讨论葡萄胎发病的危险因素。[方法]采用1∶2配比病例对照研究方法,对72例葡萄胎病例及142例对照进行问卷调查。[结果]单因素分析结果显示体力劳动类型(OR=3.378)、妊娠次数(OR=3.089)、人工流产史(OR=2.409)、夫妻年龄差距大OR=4.575)、动物油摄入(OR=2.496)、泡菜摄入(OR=2.313)、主食大米(OR=2.975)与葡萄胎的发病呈正相关,而高文化程度(OR=0.313)、豆制品摄入(OR=0.579)及胖体型与葡萄胎的发病呈负相关。经多因素分析调整后结果显示夫妻年龄差距大(OR=5.540)、体力劳动类型(OR=4.025)、人工流产史(OR=3.389)、泡菜的摄入(OR=1.717)与葡萄胎的发病呈正相关,而儿童期胖体型(OR=0.248)、青春期胖体型(OR=0.271)、成年期胖体型(OR=0.514)、高食物消费(OR=0.456)与葡萄胎的发病呈负相关。[结论]葡萄胎的发病与育龄妇女的营养状况、人工流产史、夫妻年龄差异等因素有关。

[Objective] To explore the risk factors of hydatidiform mole. [Methods] A 1 ： 2 matched eases-control study was carried out, and a questionnaire investigation was conducted in 72 cases and 144 controls. The data were analyzed by conditional logistic regression model. [ Results] Univariate analysis showed that hydatidiform mole had positive associations with physical labor type （OR = 3.378）, times of pregnancy difference of age between husband and wife （OR = 4.575） , （OR = 3.089）, history of artificial ＇abortion （OR = 2.409）, great intake of animal oil （OR = 2.496）, intake of pickled vegetable （OR = 2.313） and intake of rice （OR = 2.975） . but there were negative associations with higher educational degree （OR = 0.313）, intake of bean products （OR = 0.579）, fat body type of childhood （OR = 0.283）, fat body type of adolescence （OR = 0.537）, fat body type of adulthood （OR = 0.603） . The results of multivariable logistic regression analysis showed that hydatidiform mole laad positive associations with great difference between husband and wife （OR = 5.540）, physical labor type （OR = 4.025）, history of artificial abortion （OR = 3.389）, intake of pickled vegetable （OR = 1.717）; but had negative association with fat body type of childhood （OR = 0.248）, fat body type of adolescence （OR = 0.271）, fat body type of aduhhood （OR = 0.514）, high food consume （OR = 0.456）. [Conclusions] The hydatidiform mole is related to the nutritional status of women of childbearing age, the history of artificial abortion, the age difference between spouses and other factors.