原发性甲状腺淋巴瘤2例并文献复习

Primary thyroid lymphoma:report of two cases and review of literature

目的探讨原发性甲状腺恶性淋巴瘤(PTL)的临床病理特征和鉴别诊断。方法对2例PTL进行了光镜和免疫组化染色观察,并总结了近10年国内发表的199例PTL的详细临床资料。结果PTL多发于老年妇女,多有单侧或双侧甲状腺肿块。B细胞性PTL占94.5%(190/201),T细胞性PTL占5.5%(11/201)。结论PTL是一种罕见的甲状腺恶性肿瘤,最常见为B细胞性,其诊断和鉴别诊断主要靠病理组织学和免疫组织化学。

Objective To investigate clinicopathological characteristics and differential diagnosis of primary thyroid lymphoma （PTL）. Methods Two cases of PTL were studied and confirmed by histologic and immunohistochemical staining, and 199 cases with valid clinical information of PTL reported in literature by other authors in recent 10 years were reviewed. Results PTL occurred more often in old female , presenting as tumour in unilateral or bilateral thyroid, B-cell type were accounted for 94.5 % （190/201） and of T-cell type, 5.5 % only （11/201 ）. Conclusion PTL is a rare neoplasm. The diagnosis relies mainly on histopathological and immunohistochemical findings.