格林-巴利综合征患者血清中的抗糖脂抗体

Serum antibodies to sulphatide,GQ1b and GM1 in patients with Guillain Barre syndrome.

采用固相酶联免疫吸附法对３５例急性期格林－巴利综合征（ＧＢＳ）患者、２８例其他神经系统疾病患者和３０例健康体检者的血清中抗硫脂抗体，抗ＧＱ１ｂ及抗ＧＭ１抗体进行检测。结果：ＧＢＳ患者血清中抗硫脂ＩｇＭ抗体、抗ＧＱ１ｂＩｇＧ抗体和抗ＧＭ１ＩｇＧ抗体阳性率分别为３４％、１１％和３１％，均显著高于正常对照组。５６％的抗硫脂抗体阳性患者均有不同程度感觉障碍，而抗硫脂抗体阴性患者仅１６％（Ｐ＜０．０５）。５例有眼肌运动障碍的ＧＢＳ患者中，４例抗ＧＱ１ｂＩｇＧ抗体阳性，无眼肌麻痹的ＧＢＳ患者无１例抗ＧＱ１ｂ抗体阳性。提示不同的抗糖脂抗体可能在ＧＢＳ发病过程中起不同的作用。

We measured the serum antibodies to sulphatide, GQ1b and GM1,by enzyme linked immunosorbent assay,to 35 acute phase patients with GBS,28 disease controls,and 30 normal controls. Compared to normal control group,the anti-sulphatide IgM, anti GQ1b IgG and anti GM1 IgG levels were more frequently elevated in serum of acute GBS patients. 56% of GBS patients who had high titres of anti sulphatide antibodies had some of degree of sensory imparement, but only 16% in the GBS patients whose serum anti sulphatide antibodies serum levels were not increased.4 of the 5 GBS patientswith ophthalmoplegia had increased anti-GQ1b IgG activity, none of the GBS patients without ophthalplegia.The results suggests that each anti glycolipid antibody may play a different role in the pathogenesis of GBS.