N-取代苯并口恶嗪酮类化合物的合成及其生物活性

Synthesis and Biological Activity of N-Substituted 4H-benzoxazin-3-one

为寻求具有高生物活性的新农药化合物,以邻氨基苯酚为原料设计合成了N-取代的苯并口恶嗪酮类化合物18个,其化学结构经1H NMR及元素分析确证。初步的生物活性测试结果表明,部分化合物具有良好的除草活性,如化合物c3、c5、c6、c7和c8在浓度为100mg/L时对苋菜Ambrosia tricolorL inn.的抑制率达90%。

In search of novel compounds with high biological activities, 18 N-substituted benzoxazinone derivatives were designed and synthesized. Their chemical structures were confimed by ^1H NMR and elemental analysis. Preliminary bioassays showed that some of them have good herbicidal activity. The inhibition rate of c3 ,c5 ,c6 ,c7 and c8 to Ambrosia tricolor Linn. was up to 90% at the concentration of 100 mg/L.