摘要
为了研究2-仲丁氨基-5-(2-氯吡啶-4-基)-1,3,4-噻二唑(BCPT)的结构-活性关系和开发活性更高的新型除草剂,以BCPT为先导化合物,依据活性亚结构连接法,在吡啶环2-位上引入二芳醚类除草剂的典型结构单元——芳醚,设计并合成了一系列新的芳氧吡啶噻二唑类化合物,其结构经元素分析和^1H NMR确证。初步除草活性测定结果表明,在500mg/L剂量下,所有化合物的除草活性(抑制率0-45%)远低于先导化合物(抑制率72%-87%),说明吡啶环2-位上的氯原子可能对维持该类化合物的除草活性是必需的。
2-sec-Butylamino-5 - ( 2-chloropyrid-4-yl ) -1,3,4-thiodiazole ( BCPT ) is a herbicidal leading compound. In order to improve its herbicidal activity and study the relationship between chemical structure and bioactivity, an aryl ether moiety was introduced to the sketch and a new series of compounds were synthesized and the structures were confirmed by ^1H NMR and elementary analysis. Preliminary bioassay showed that all the synthesized compounds just showed a poor inhibition rate (0 45 % ) at 500 mg/L, much weaker than (BCPT) (72 % - 87 % ). The result suggested that chloro-atom on 2-position of pyridine ring may be indispensable for herbicidal activity.
出处
《农药学学报》
CAS
CSCD
2007年第2期189-192,共4页
Chinese Journal of Pesticide Science
基金
国家自然科学基金课题(20472112)
国家"十五"科技攻关课题(2004BA308A22-1)
关键词
二芳醚
吡啶衍生物
1
3
4-噻二唑
除草活性
diaryl ether
pyridine derivatives
1,3,4-thiodizole
herbicidal activity