1,2,4-三嗪类化合物的研究(ⅪⅤ)——3-甲氧基-5-甲基-6-乙酰-1,2,4-三嗪的合成及其与芳香醛的反应

Chemistry of 1,2,4-Triazines(XIV)——Synthesis of 3-Methoxy-5-Methyl-6-Acetyl-1,2,4-Triazine and Its Condensation with Aromatic Aldehydes

5或6-取代芳乙烯基-1,2,4-三嗪类化合物具有广谱抑菌活性,本文将3-甲氧基-5-甲基-6-乙酰-1,2,4-三嗪(Ⅱ)在HCI/AcOH体系中与芳香醛进行缩合反应,分别得到3-甲氧基-5-甲基-4′-羟基-肉桂酰基-1,2,4-三嗉(Ⅲ)和3-甲氧基-6-乙酰-5-[2-取代芳基-乙烯基]-1,2,4-三嗪(Ⅳ)。

3-Methoxy-5-methyl-6-acetyl- 1, 2, 4-triazine ( Ⅱ ) was synthesized and condensed with aromatic aldehydes to give 3-methoxy-5-methy]-6-(4-hydroxy)-cinnamy)-] ,2. 4-triazine( Ⅲ ) or 3-methoxy-6-acetyl-5-(2-aryl)-vinyl- 1, 2, 4-triazines ( Ⅳ ). The structure of these products were proved by IR, UV, MS, 1H and 13C NMR spectra.