应用脱钙骨基质和硫酸钙颗粒治疗骨缺损的初期结果

The early clinical effect of decalcification bone matrix and OSTEOSET in treating the bone defect

目的探讨使用骨移植替代物脱钙骨基质（DBM）和硫酸钙颗粒（OSTEOSET）治疗骨缺损的疗效。方法对同期手术治疗的52例骨缺损患者的缺损处,分别于术后第1、4、8周及3、6、12个月进行随访并摄X线片直至骨缺损愈合。统计分析患者的临床资料、X线片辅助分析骨缺损修复程度和并发症。结果随访8-12个月,植骨术后6、12个月分别有95%和99%患者的骨缺损显示有明显的新骨形成,修复水平为60%-100%。并发症为3例（5.77%）,经换药后治愈,未发生骨缺损不愈合。结论DBM和OSTEOSET在骨愈合早期可加速骨缺损的修复,并可作为新鲜自体髂骨的替代物。

Objective To evaluate the effect of decalcification bone matrix （DBM） and OSTEOSET in treating the bone defect. Methods 52 patients with bone defect were treated with DBM and OSTEOSET. Every patient was followed up until the bone defect was healed at the 1,4, 8 weeks and 3, 6, 12 months. The clinical data and the recovery of the bone and the complication of the operation were analyzed. Results The follow-up of all cases ranged from 8 to 12 months. 6 months after operation, there was visible new bone in 95% of all patients and 99% 12 months later. The level of bone reparation is between 60% and 100%. 3 cases had complications（5.77% ） ,and healed after dress changing. No bone defect was disunioned. Conclusions DBM and OSTEOSET can accelerate bone reparation and take place of bone autograft as good implant substitute.