丙氧匹林的镇痛效应和急性毒性研究

STUDY ON ANALGESIC EFFECT AND ACUTE TOXICITY OF PROPOXYPIRIN

用小鼠乙酸扭体法、热板法和大鼠甩尾法测定了丙氧匹林片（右丙氧芬１００ｍｇ，阿斯匹林２５０ｍｇ）的镇痛效应，并进一步测定其急性毒性。镇痛强度：小鼠热板法和乙酸扭体法的ＥＤ５０值分别为１５８和６．０９ｍｇ／ｋｇ，大鼠甩尾法ＥＤ５０为１５１ｍｇ／ｋｇ；急性毒性：ＬＤ５０大、小鼠分别为６１６和９６０ｍｇ／ｋｇ。结果表明：同右丙氧芬相比，丙氧匹林有较好的镇痛作用及剂量效应关系，且毒性较低。提示丙氧匹林可能是一疗效更好的镇痛药。

Propoxypirin is a combined formulation containing 100 mg propoxyphene and 250 mg aspirin.Its analgesic effect was studied in rats by tail flicking test and in mice by acetic acid induced twitching and hot plate test.Its acute toxicity was also studied in both rats and mice.The results obtained are listed bellow: Analgesic ED 50 (mg/kg)LD 50 (mg/kg)MiceHAC induced twiching6.09960Hot plate test158RatsTail flicking test151616