中链甘油三酯对2型糖尿病肥胖和炎症反应的影响

The Effects of Medium Chain Triglyceride on Obesity and Inflammatory Reaction in Type 2 Diabetes Mellitus

目的探讨中链甘油三酯干预对2型糖尿病患者肥胖和炎症反应的影响。方法中链甘油三酯组、中链甘油三酯+长链甘油三酯组和长链甘油三酯组2型糖尿病患者,在控制总能量和脂肪摄入量的基础上,连续食用100%中链甘油三酯油、50%中链甘油三酯油+50%长链甘油三酯油和100%长链甘油三酯油12周。在0、6和12周时,测量身高、体重、腰围和臀围,检测血浆炎症相关性脂肪因子脂联素、单核细胞趋化蛋白1和外周血单个核细胞过氧化体增殖物激活型受体γmRNA的表达水平,计算体质指数和腰臀比。结果在6周和12周时,中链甘油三酯组和中链甘油三酯+长链甘油三酯组的体重、腰围和体质指数均比长链甘油三酯组低,在12周时,中链甘油三酯组的腰臀比明显小于长链甘油三酯组。在6周时,中链甘油三酯组和中链甘油三酯+长链甘油三酯组的血浆脂联素水平均比长链甘油三酯组高,12周时中链甘油三酯+长链甘油三酯组的血浆脂联素水平比长链甘油三酯组高,6周时中链甘油三酯组血浆单核细胞趋化蛋白1水平比长链甘油三酯组低。结论在控制总能量和脂肪摄入量的基础上,用中链甘油三酯取代100%或50%的膳食油脂,具有降低2型糖尿病患者体重和腰臀比的效果,且帮助减轻机体炎症反应水平,从而降低发生动脉粥样硬化的危险性。

Aim To observe the effects of medium chain triglyeeride （MCT） on obesity and inflammatory reaction in type 2 diabetics mellitus （T2DM）. Methods With total energy and fat consumption controlled, MCT group＇s patients took 100% MCT oil, MCT＋ long chain triglyceride （LCT） group＇s patients took 50% MCT oil＋ 50% LCT oil and LCT group＇s patients took 100% LCT oil for 12 weeks. Blood Adiponectin and monocyte chemoattractant protein 1 （MCP-1）, mRNA expression of peroxisome proliferator activated receptor γ （PPARγ） in peripheral blood mononuclear cell were detected, body height, body weight, waistline and hipline were measured at 0 , 6 and 12 week. Then body mass index （ BMI ） and waist-hip ratio （WHR） were analyzed. Results Compared with LCT group, body weight, BMI and waistlines of 6 and 12 week in MCT and MCT ＋ groups were decreased and WHR of 12 week in MCT group was much decreased. Compared with LCT group, plasma adiponectin of 6 week in MCT and MCT＋ LCT groups were higher, plasma adiponectin of 12 week in MCT＋ LCT group were higher. Compared with LCT group, plasma MCP-1 of 6 wk in MCT group was lower. Condusions With total energy and fat consumption controlled, the daily diet oil is replaced full or partly by MCT, the body weight and WHR decrease and the inflammatory reaction ameliorate in T2DM patients. So MCT possibly help to reduce atherosclerosis risk.